Growth Promotion Test, To verify that the culture media is capable to growth in order to use in Microbiology Test specified in Pharmacopoeia.
Scope of Growth Promotion Test:
This SOP applies for verification of the effectiveness of culture media which is used in Microbiology Laboratory at XX Pharmaceuticals Limited.
Definitions/Abbreviation :
CFU : Colony Forming Unit
CSDA : Casein Soyabean Digest Agar
CSDB : Casein Soyabean Digest Broth
GPT : Growth Promotion Test
SDA : Sabouraud Dextrose Agar
SDB : Sabouraud Dextrose Broth
TAMC : Total Aerobic Microbial Count
TYMC : Total Yeast & Mould Count
Responsibilities:
The roles and responsibility is summarized as follows:
Executive, Microbiology
To execute Inoculation, incubation of Culture media and plate count of Growth Promotion Test.
Assistant Manager/Manager, Microbiology
To ensure Growth Promotion Test, documentation and application of sound technical information.
Head of Quality Assurance
Approval of this SOP
Procedure:
Note:
Don’t move forcefully into the test area. Move always gently.
Disinfect all apparatus using 70% IPA before transfer into the Laminar Air Flow.
When enter into test area, wear sterile latex free gloves, lab coat/apron and eye protection (when required).
To prevent the unauthorized contamination, make sure that all personal ornaments, all type of cellular phone are left before enter into the test room.
General Requirement :
Glass Apparatus :
Pipette 2 ml, 10 ml
Screw Capped Test Tube
Sterilized 90 mm Glass Petridish
Screw capped Conical Flask 100 ml
Volumetric Flask 500 ml
Volumetric Flask 1000 ml
Media and Reagents:
Meat peptone
Neutralized Peptone
Selected Media
Others Requirements:
70% IPA or ethanol
0.45 µm Membrane Filter
Forceps
Filtration Unit( sterilized filter disk and filtering funnel)
Glass spreader
Scissors
Surgical Gloves
Surgical Cotton
Test Conditions:
Monitoring the testing area using by Microbial Air Sampler during working day.
Perform test under LAF to avoid any type contamination.
Culture Media Preparation:
Prepare different culture media as per specific requirement
Weigh the amount declared in the manufacturer label into the appropriate flask.
Bring to boil completely to dissolve media.
Sterilize at 1210C for 15 minutes or as per Manufacturer declaration mention on the label.
Store the prepared culture media in air tight flask controlled room temperature at controlled environment
Store prepared agar media at (2-8)0C
Preserve the dehydrated culture media up to its expiry date.
Never use the expired culture media.
Use agar media when the temperature reduce near at 450C and cool in case of broth media.
Stock Buffer Solution:
Place 34 g of Potassium Dihydrogen Phosphate[KH2PO4] in the 1000 ml volumetric flask
Dissolve in 500 ml of Purified Water then adjust to pH (7.2 ± 0.2) and dilute to make 1000ml with Purified Water.
Dispense 90 ml into each screw capped flask [5 or more flask required].
Sterilize at 1210C for 15 minutes.
Keep the prepared buffer solution at (2-80C) for a validated period.
Glassware Cleaning & Sterilization:
First of all clean all glassware with 1% detergent and then rinse with sufficient tap water.
Finally Rinse with sufficient Purified Water to remove the residual content of detergent.
Sterilize all glassware with Dry Heat Sterilizer at 2000C for 1 hour.
General Procedures
Growth Promotion Test (GPT) of General Media
Carry out Growth Promotion Test for each prepared culture media.
Prepare standardized suspension for the different test strains as mentioned in Table 1
Use sterile Buffer Sodium Chloride [NaCl]-Peptone solution where pH 7.0 or Phosphate Buffer which pH 7.2 as respective diluents.
Use the standard test strains are not more than 5 passages from original master seed lot.
During preparation of Aspergillus brasiliensis suspension, add 0.5% Polysorbate 80 to the buffer solution.
Use the suspension within 24 hours when preserve at (2-8)0C otherwise use within 2 hours.
Freshly prepare the Bacillus subtilis and A. brasiliensis suspension and store at (2-8)0C for validated period, then dilute it for use.
Inoculate distinctly 100 cfu of each microorganism to 10 ml of each liquid media & follow spread plate method for solid media as mention in Table 1.
Incubate the medium for fungi at (20-25)0C for 5 days and for bacteria at (30-35)0C for 3 days.
Interpretation of Results:
Liquid media is suitable for use, if growth found, then it is clearly on each media.
Solid media is suitable when count is not greater than 2 from the calculated value of the standardized value.
Inoculation and Dilution:
Add the sufficient volume of suspension of inoculums to the sample to maintain not more than 100 cfu
Add inoculums suspension not more than 1% of the diluted product.
Prepare lowest possible dilution for tolerable microbial recovery of sample
When sample contains any antimicrobial properties add the neutralizer to remove Interfering factor.
When growth is inhibited then increase the use of diluents or membrane filtration or combination of all above.
Add (20-25) ml of SCDA[Soyabean Casein Digest Agar] & SDA[Sabouraud Dextrose Agar] to 90 mm diameter petridish at least duplicate.
Incubate the medium for bacteria at 30-350C for 3 days and the medium for fungi at 20-250C for 5 days.
Interpretation of Results :
Liquid media is suitable for use, if growth found, then it is clearly on each media.
Solid media is suitable when count is not greater than 2 from the calculated value of the standardized value.
Growth obtained must not be differing by a factor greater than 2 from the calculated value for standardized inoculums for Solid Media, For freshly prepared inoculums, growth of the micro-organisms comparable to that previously obtained with a previously tested and approved batch of medium occurs.
Growth Promotion Test of Selective Media:
Growth Promotion & Inhibitory Test :
Perform this test for each prepared media.
Inoculate the each media not more than 100 cfu microorganisms as per Table 2
Perform surface-spread method for solid media
Incubate the media as per specified in that microorganisms.
Interpretation of Result :
The media is suitable for use if growth found clearly in liquid media and found the specific colony characteristics on solid media.
Inhibitory test is failed when no growth found occurs the specific colony.
Test for E. coli :
Add the specific microorganism to 100 ml of CSDM. Incubate at 30-350C for 18-24 hours.
Shake the container, transfer 1 ml of SCDA[Soyabean Casein Digest Agar] to 100 ml of MacConkey Broth. Incubate at [42-44]0C for 24 hours.
Subculture on MacConkey Agar plate from MacConkey broth. Incubate at 30-350C for 18-72 hours.
GPT of that culture media complies with the test for E. coli if the red colonies are present with precipitated zone & the biochemical tests are negative[-ve].
Test for Salmonella
Add the specific microorganism in 100 ml of CSDM. Incubate at 30-350C for [18-24] hours.
Shake the container, transfer 0.1 ml of CSDM to 10 ml of Rappaport Vassiliadis Salmonella (RVS) Broth. Incubate at 30-350C hours for 18-24 hours.
Subculture on Xylose Lysine Deoxycholate (XLD) Agar plate from Rappaport Vassiliadis Salmonella (RVS) Broth. Incubate at [30-35]0C for [18-48] hours.
GPT of that culture media complies for Salmonella if no red colonies are present with or without black centres and the biochemical tests are negative.
Test for Pseudomonas aeruginosa
Add the specific microorganism to 100 ml of CSDM. Incubate at 30-350C for 18-24 hours.
Subculture on the Cetrimide Agar plate from CSDM. Incubate it at 30-350C for 18-72 hours.
GPT of that culture media complies with the test for Ps. aeruginosa if no bluish green colonies are present & the biochemical tests are negative[-ve].
Test for staphylococcus aureus
Add the specific microorganism into 100 ml of CSDM. Incubate it at (30-35)0C for 18-24 hours.
Sub-culture on Mannitol Salt Agar plate from CSDM. Incubate at (30-35)0C for 18-72 hours.
GPT of that culture media complies with the test for St. aureus if no yellow/white colonies
Surrounded yellow zone are present and the biochemical tests are negative.
Test for Candida albicans
Add specific microorganism to 100 ml of Soubaurad Dextrose Broth(SDB). Incubate at (30-35)0C for (3-5) days.
Subculture on Soubaurad Dextrose Agar[SDA] plate from SDB[Soubaurad Dextrose Broth]. Incubate at [30-35]0C for [24-48] hours.
GPT of that culture media complies with the test for C. albicans if no white colonies are present and the biochemical tests are negative[-ve].
Growth Promotion Test Report Preparation:
Prepare Report in Growth Promotion Test Report of General Culture Media, Annexure-I & Growth Promotion Test Report of Selective Culture Media, Annexure-II.
Preventive Maintenance: This SOP [Preventive Maintenance] will make as per SOP for SOP of the respective company/Organization. Font/line spacing/Margin/Page set up/Header/Footer etc. will change as per requirement of SOP for SOP.
1.0 Purpose: The purpose of this SOP is to describe the measures involved in conducting and managing preventive maintenance activities of the machines/equipment of XX Pharmaceuticals Limited.
2.0 Scope: This procedure applies to all machines/equipment of Production, Product Development [PD] and sampling area of every Blocks of XX Pharmaceuticals Ltd.
3.0 Abbreviation/Definitions
SOP: Standard Operating Procedure.
PM: The Preventive maintenance can be defined as to the routine maintenance which prevent the unwanted failure of any machine and keep the machine in working condition. The successful maintenance program prevent any type unwanted failure of running machine. To execute the successful maintenance program a schedule must be prepare and maintain the same.
4.0 Responsibilities:
The roles and responsibilities are described below:
4.1 Equipment Numbering and Database Maintaining
Validation Personnel [Engineering Department]
To maintain the Equipment Numbering System of the Equipment Database based on Excel Tracker.
To make the preventive maintenance proposal in accordance with the production planning.
To arrange the equipment list for Preventive Maintenance help of Maintenance engineer, comprising the maintenance intervals listed in respective section.
4.2 Setting up Preventive Maintenance for New Equipment
Head of Engineering/Designee
To ensure that all critical equipment’s are identified and are entered in the Equipment database.
To approve new Preventive Maintenance Planning and take initiative to if required changes to existing Preventive Maintenance Planning based on-
Equipment consumption.
Trending of maintenance antiquity (existing alike equipment).
Safety and legal necessities.
Discussion with the User, Technician and Engineering Executive
Merchant’s manuals and references
Engineering Executive
Inform the relevant departmental Head about the new routines and to ask appropriate time for Preventive maintenance prior to making PM Plan.
To update a list of spare parts based on the manufacturer’s references and to refer the list to the Planning and Procurement department [PPD] with a request to place order if required.
To support for arranging the PM schedule.
To check and ensure that the logbook is filled up by the technicians.
4.3 Preventive Maintenance Routine and Schedule
Maintenance Technician
To switch off the power and keep out the switch where the performing of maintenance activities does not involve any electrical connection and to retain the equipment entire time in lockout mode.
Before initiating the work, check the accurate equipment label has been attached to the equipment and it imitates to the equipment number based on the PM record datasheet.
To fill up the “PM record datasheet” upon accomplishment of activities.
Engineering Executive
To check and ensure that the “Preventive maintenance record datasheet” is filled up completely and to sign it upon completion of work.
To check that PM work is complete and to inform the area manager that the machine is ready for action.
4.4 Managing & Preserve Equipment Maintenance History File
Head of Engineering/Designee
To ensure that the PM planning table is kept up-to-date. If required, to refresh the schedule on a monthly basis or sooner.
To monitor the activities of the Engineering Executive performing the PM work and to provide technical support and assistance with documentation requirements. Also to ensure that PM work for particular equipment is completed within 30 days of scheduled PM date.
Validation Department [Engineering]
To uphold and preserve the equipment maintenance history files, maintenance instructions and associated documents at Engineering Department.
Head of Engineering/Designee
To confirm that the equipment maintenance history files are secured at Engineering Department.
4.5 Trend Analysis and Follow up Action
Head of Engineering/Designee
To check and review the history files of equipments maintenance annually and to find out the time of occurrence of major failures and to identify the repeated component of failures or other events.
5.0 Revision Details:
Sl. No. / Version No./ Effective Date/ Change History-will be se entitled in separate column.
6. Annexures:
List of Annex has been mentioned at the bottom of this document
7. Procedure:
Note: All maintenance work must be accomplished carefully in accordance with the necessities of the Plant Safety Declaration and the safety notices from place to place in the plant. Definite attention must be paid in the following:
a) Equipment must be electrically inaccessible and locked out where possible.
b) Personal Protective Equipment [PPE] and clothing suitable to the assign job must be worn.
7.1 All serious equipments must be acknowledged and PM processes must be set up with defined interludes and must be incorporate in the PM schedule.
7.2 PM plan is organized prior to performing the activities. For the production equipment this plan is prepared based upon the settlement with the Head of Plant Operations.
7.3 The lists of equipment/machine for preventive maintenance are to be provided in a separate Annexure. If any equipment/machine needs to be added or deducted from the list, Head of Quality Assurance/Designee will do it by hand writing it with signature with date without reviewing the entire SOP. The list will be restructured during next revision of this SOP.
7.4 There is a checklist included in the respective section for every equipment/machine which are undergone PM. The maintenance logbook of every equipment/machine will be store in the respective room and the technicians or engineering persons who are involved in doing the maintenance work will be liable to fill up the logbook upon close of the task. The forms will be store in the room of the respective machine in the shop floor.
7.5 “Under Maintenance”[Annexure-III]: status label must be attached on the machine by the engineering personnel during preventive maintenance activities.
7.6 “Shifting in Progress for Maintenance”[Annexure-IV] status label must be placed by the engineering personnel on the machine at the time of shifting for maintenance activities.
7.7 Status label of “Preventive Maintenance”[Annexure-V] must be affixed by the engineering personnel on the machine after completion of preventive maintenance.
7.8 Photocopy of all approved forms to be used where easily applicable. Computer Generated form with exact format can be used with mentioning the following note at footer:
“This is a computer generated report and the format is as per the original approved form”
7.9 PM schedule [Annexure-I] must followed accordingly. The monthly preventive maintenance scheduling table should be circulated to the relevant department at the starting of every month and engineering department must keep a copy of the PM schedule.
7.10 Preventive maintenance schedule/plan may be changed if any requalification is carried out due to major modification or breakdown.
7.11 PM records/history[Annexure-II] must be reviewed to facilitate, evaluate and improving the performance of the PM programme and the performance of the Equipment/Machine.
7.12 Frequency/Interval of preventive maintenance schedule/Plan of a machine/equipment can be revised based on the frequency/interval and nature of breakdown happened in the past as per trending/trend analysis of the specific machine.
7.13 When the preventive maintenance of an equipment/machine is completed, successful trial will be run and the respective engineer will hand over/transfer/deliver the machine to the relevant departmental head/designee.
7.14 Maintenance activities of a number of equipment’s/machines:
The maintenance activities of various equipment’s/machines of XX Pharmaceuticals Ltd. are described here:
Fluid Bed Dryer:
Maintenance Interval: Monthly
Maintenance Task:
Check the blower housing and drain for the possible condensate
Check smooth operation of the blower
Clean locking bolt using grease
Check the Heat Exchanger
Inspect All Screw Connection In-Process Piping System
Maintenance Interval: 6 Monthly
Maintenance Task:
Check all O-Ring and adjustment if it is necessary
Check the filter elements aimed at contamination
Exchange filter elements, if there is any perceptible damage
Maintenance Interval: Yearly
Maintenance Task:
Check the blower motor mount screws for tightness
Check pneumatic inflatable gasket
Check the all silicon gasket seals
Coating Machine:
Maintenance Interval: Monthly
Maintenance Task
Check the pneumatic system
Check and clean the pre filter
Check the spray gun & air connection
Check the pan motor, gear box drive belt
Check the pan bearing & gear box bearing
Check the door seal, pan bearing, hinges, and tightness
Check the blower motor, blower housing & heat exchanger
Check the solution mixing pneumatic motor and grease the bearings
Check the flow switch, water solenoid valve, bar limit switch & hose retighten
Maintenance Interval: 6 Monthly
Maintenance Task
Check the spray pump
Check the Electrical Wire Connection
Check the main gear box & gear oil level
Grease the bearing and if it is damaged then replace the same
Yearly
Check the gear oil level and add oil if it is necessary
Check the door seals, pan bearing, coupler hinges and joints
Check the blower motor and heat exchanger unit motor hose
Blister Machine:
Maintenance Interval: Monthly
Maintenance Task
Check the Heater
Check the Cam Bearing
Check the Gear Oil Level
Check the Electrical Connection
Check the Pneumatic Connection
Maintenance Interval: 6 Monthly
Maintenance Task
Check the Blade
Check the Spring Tension
Check the electrical connections
Check the Roller Bearing & Bearing Pin
Maintenance Interval: Yearly
Maintenance Task
Check the Air filter
Check the Lubricated spring set
Check the Gear oil and change if it is necessary
Check the Oil spring set, if damage than change the same
Autoclave:
Maintenance Interval: 03 Monthly
Maintenance Task
Check the door seal.
Check the gasket of all TC clamp connections.
Check for any lime build up in the vacuum pump discharge pipe.
Maintenance Interval: 06 Monthly
Maintenance Task
Check the strainers fitted with the machines
Check the pneumatic valve & solenoid valve seal and gasket
Check the operational status of the non return valve fitted on sterilizer
Maintenance Interval: Yearly
Maintenance Task
Check the all electrical connections
Check the emergency button is working properly
Visually check the condition of the mechanical chain
Check the pneumatic cylinder opening/closing the door
Visual check for any water leakage from the vacuum pump body
Encapsulation Machine:
Maintenance Interval: Monthly
Maintenance Task
Check the Gear Oil Level
Check the Vacuum Oil Level
Check the Bearing Condition
Check the Electrical components
Check the Main Motor Connections
Check the Powder Sensor Sensitivity
Maintenance Interval: Half Yearly
Maintenance Task
Refill Vacuum Oil if necessary
Check Gear Oil and change if necessary
Bottle Washing Machine:
Maintenance Interval: Monthly
Maintenance Task
Check the filters
Check the gear box
Check the float switch
Check the pneumatic line
Clean the electrical panel board
Check the nozzle and clean it if necessary
Maintenance Interval: 3 Monthly
Maintenance Task
Check the Gear oil level
Check the bearing condition
Check the main motor connection
Check the electrical all components
Maintenance Interval: 6 Monthly
Maintenance Task
Check the Gear oil and change the same if required.
Conveyer Belt:
Maintenance Interval: Weekly
Maintenance Task
Check the main motor
Check the roller bearing
Check the gear box with oil
Check the roller adjustment belt
Check the chain, clean and grease
Maintenance Interval: Monthly
Maintenance Task
Check the Gear oil level.
Check the electrical all component.
Maintenance Interval: Yearly
Maintenance Task
1. Check and change gear oil if it is required.
De-duster Machine:
Maintenance Interval: Weekly
Maintenance Task
Check the main motor
Check the roller bearing
Check the gear box with oil
Check the roller adjustment belt
Check chain and clean and grease
Maintenance Interval: Monthly
Maintenance Task
Clean the Electrical panel board.
Check the gear oil and change, if it is needed.
Blending Machine:
Maintenance Interval: Monthly
Maintenance Task
Check all safety interlock and mechanisms.
Check the machine for irregular noise or vibration.
Check compressed air filter and clean/change if required.
Check Pneumatic System (Air Condition Filter and Regulator)
Maintenance Interval: Yearly
Maintenance Task
Check the double cone tool
Clean the electrical cabinet sensibly
Check the Gear Oil Level If need then replace
Check for any unfamiliar noise or shaking from the machine
Two Head Liquid Filling Machine:
Maintenance Interval: Monthly
Maintenance Task
Check the roller bearing
Check the gear box with oil
Check the piston and the disks
Check the main motor with v-belts
Check and grease all movable parts
Maintenance Interval: 6 Monthly
Maintenance Task
Check the overall cleaning
Check the electrical all component
Check the pistons and disks for any damage
Manufacturing Vessel:
Maintenance Interval: Monthly
Maintenance Task
Check gear box with oil
Check main motor with V-belt
Check roller bearing of the pump
Check and grease all movable parts
Check the transfer pump of the vessel
Maintenance Interval: half Yearly
Maintenance Task
Check the overall cleaning
Check the electrical all component
Check the mechanical seal of the pump
Tablet Compression Machine:
Maintenance Interval: Monthly
Maintenance Task
Check the V-belt
Check the main shaft
Check the warm gear
Check the pressure roller
Check the electrical cabinet
Check the pressure adjust knob
Maintenance Interval: 6 Monthly
Maintenance Task
Check the filling depth
Check the Gear oil level
Check the hydraulic oil level
Check the electrical connection
Check the powder level sensor
Maintenance Interval: Yearly
Maintenance Task
Check the Gear oil viscosity
Check the electrical component
Check the Hydraulic oil if need replace it
Cap Sealing Machine:
Maintenance Interval: 6 Montly
Maintenance Task
Check the gear oil level
Check the cap sealing holder
Check the motor piston with grease
Check the pressure adjustment knob
Check the bearing with gear premium
Maintenance Interval: Yearly
Maintenance Task
Check the pneumatic motor
Check the electrical cabinet
Check the pressure adjustment knob
Check the motor with bearing piston grease
Check the gear oil level if need change the same
Stability Chamber:
Maintenance Interval: Monthly
Maintenance Task
Clean the PT100 Sensor
Check the door pipe connection
Check the chamber door closing
Check the operations of safety thermostat
Check the condenser fan, if found loose then tighten it
Check the proper earthling connection to the stability chamber
Maintenance Interval: Half Yearly
Maintenance Task
Check the evaporation tray
Clean the condenser by blower air through
Check the water immersion heater and reservoir tank
Check the side port hole is properly fitted with rubber cork
7.14.16 Rapid Mixer Granulator of Product Development:
Maintenance Interval: Monthly
Maintenance Task
Check the pneumatic component
Check the electrical wire connection
Check any unusable noise or vibration
Check all safety interlock and mechanism
Maintenance Interval: 6 Monthly
Maintenance Task
Check the electrical wire connection
Check the oil level and viscosity of oil manually
Rapid Mixer Granulator of Product department:
Maintenance Interval: Monthly
Maintenance Task
Check the main motor with gear
Check the chopper motor bearing
Check the impeller and motor bearing condition
Maintenance Interval: 6 Monthly
Maintenance Task
Check the Electrical Wire Connection
Check the V-Belt & Motor Condition
Check the Mechanical Seal or Bearing
Check the Main Gear Box Gear Oil Level
Maintenance Interval: Yearly
Maintenance Task
Check the discharge valve’s motor condition.
Check the gear oil level if it is needed then replace the same.
Sampling Booth:
Maintenance Interval: fortnightly
Maintenance Task
Clean the pre filter (G4).
Check the motor condition.
Check the machine’s all nuts and bolts.
Maintenance Interval: Monthly
Maintenance Task
Clean blower motor.
Check electrical constituents & motor.
Check for any unfamiliar noise or vibration.
Dispensing Booth:
Maintenance Interval: Forthightly
Maintenance Task
Clean pre filter (G4).
Check the motor condition.
Check the machine’s all nuts and bolts.
Maintenance Interval: Monthly
Maintenance Task
Clean the blower motor.
Check electrical components and motor.
Check for any unfamiliar noise or vibration.
Solution Mixing Tank:
Maintenance Interval: 6 Monthly
Maintenance Task
Check the baffle plate
Check the pneumatic motor
Check the pressure adjustment knob
Check the pneumatic motor piston grease
Maintenance Interval: Yearly
Maintenance Task
Check the baffle plate
Check the pneumatic motor
Check the Pressure Adjustment knob
Check the pneumatic motor piston grease
Vacuum Pump
Maintenance Interval: Fortnightly
Maintenance Task
Clean the filter
Clean the O ring
Check the nut bolt
Check the motor condition
Maintenance Interval: Yearly
Maintenance Task
1. Clean the blower motor
2. Check the electrical all component and motor
Vibratory Shifter:
Maintenance Interval: Monthly
Maintenance Task
Check housing flange
Check the motor body
Check the motor flange
Check electrical Components
Maintenance Interval: 6 Monthly
Maintenance Task
1. Check the motor electrical connection
2. Check the motor bearing house with bearing
Powder filling machine:
Maintenance Interval: 6 Monthly
Maintenance Task
Check airline
Check gear box
Check all grease point
Check all pulley and Belt
Check vibration and abnormal noise
Check all screws on driving units, tighten it if necessary
Maintenance Interval: Yearly
Maintenance Task
Check the earthing
Check the switches
Check voltage and frequency
Sticker Labeling Machine:
Maintenance Interval: Monthly
Maintenance Task
Check the pneumatic system
Lubricate the motor bearing as needed
Check all screws on driving units & tighten it if required
Maintenance Interval: Yearly
Maintenance Task
Check the earthing
Check the inverter connection
Check the voltage & frequency
Check the electrical control unit
Automatic Dehumidifier:
Maintenance Interval: Monthly
Maintenance Task
Check the fan.
Check for somewhat leakage
Check the cooling coil
Check the gas pressure of the compressor
Remove the condenser water from container
Check the screw on driving units & tighten it if needed
Maintenance Interval: Yearly
Maintenance Task
Check the electrical switches
Check the electrical connections
Tablet De-duster:
Maintenance Interval: Monthly
Maintenance Task
Check the main motor
Check the gear oil level
Check the roller bearing
Check the gear box with oil
Check the roller adjustment belt
Check the electrical all component
Check the chains and clean & grease
Maintenance Interval: Yearly
Maintenance Task
Check the electrical panel board & overall cleaning
Check the viscosity of gear oil & change it if necessary
Inkjet Printer:
Maintenance Task
Maintenance Interval: Monthly
Check the vacuum pump
Check the ink spray needle
Check the electrical cabinet
Check the solvent or ink status
Check the pressure adjust knob
Check the main ink head of printer
Inkjet Printer:
Maintenance Task
Maintenance Interval: Monthly
Check the main head
Check the vacuum filter
Check the ink expire date
Check the electrical connection
Check the ink or solvent level sensor
Vial Washing Machine:
Maintenance Interval: Monthly
Maintenance Task
Check the Nozzle
Check the Gear Box
Check the Float Switch
Check the Pneumatic Line
Check the Electrical Panel Board
Check the Pneumatic Line, Connector & Filter
Maintenance Interval: 3 Monthly
Maintenance Task
Check the Gear Oil Level
Check the Hot Water Line
Check the Bearing Condition
Check the Main Motor Connection
Check the Electrical All Component
Check the Powder Sensor Sensitivity
Check the Turret and Moving Parts Clean and Grease
Maintenance Interval: 3 Monthly
Maintenance Task
Change the Gear Oil
Refill the Vacuum Oil
Clean the Overall Machine
Multi Mill:
Maintenance Interval: Monthly
Maintenance Task
Check the pulley
Check the hopper will blades
Check screws on driving units, tighten it if required
